Industrial Manufacture of Medicines

Macroarea: Pharmaceutical Technology

ERC Sectors: LS7_3 Nanomedicine; LS6_13

Research Team

Lab Manager: Lauretta Maggi (PA)

Junior Staff: Valeria Friuli (Borsista)

Research Lines

1. Study, production, quality control and stability tests of immediate release and modified release pharmaceutical forms.

2. Innovative methods for increasing the dissolution rate of poorly soluble drugs or drugs with pH dependent solubility for oral administration.

3. Design and scale-up of pharmaceutical formulations mainly for the oral route.

4. In vitro evaluation of commercial medicines for human and veterinary use.

5. Application of electro-spinning to the formulation for pre-programmed drug release

Publications
  • The peculiar behaviour of piretanide hosted in layered double hydroxides. Marianna Guagliano, Francesco Monteforte, Giovanna Bruni, Valeria Friuli, Lauretta Maggi, Irene Quinzieri, Marcella Bini. Applied Clay Sci. (2020) 198 105826. https://doi.org/10.1016/j.clay.2020.105826
  • Zaltoprofen/4,40-Bipyridine: A Case Study to Demonstrate the Potential of Differential Scanning Calorimetry (DSC) in the Pharmaceutical Field. Giovanna Bruni, Lauretta Maggi, Francesco Monteforte, Chiara Ferrara, Doretta Capsoni, Vittorio Berbenni, Chiara Milanese, Alessandro Girella, Valeria Friuli, Piercarlo Mustarelli, Amedeo Marini. J. Pharm Sci. (2021) . https://doi.org/10.1016/j.xphs.2021.08.009
  • Hybrid compound for improving drugs solubility: synthesis, physic-chemical and pharmaceutical characterization of Nimesulide-LDH. Bini M., Monteforte F., Quinzieni I., Friuli V., Maggi L., Bruni G. Journal of Solid State Chemistry. 272 132-137 (2019) https://doi.org/10.1016/j.jssc.2019.02.001
  • Physico-chemical and pharmaceutical characterization of sulindac-proglumide binary system. Bruni G., Sakaj M., Berbenni V., Maggi L., Friuli V., Girella A., Milanese C., Marini A. Journal of Thermal Analysis and Calorimetry, 136, 2063-2070 (2018) https://doi.org/10.1007/s10973-018-7858-7
  • Meloxicam-LDH hybrid compound: a succesful strategy to improve solubility. Monteforte F., Bruni G., Quinzeni I., Friuli V., Maggi L., Capsoni D., Bini M. Journal of Inorganic and Organometallic Polymers and Materials. https://doi.org/10.1007/s10904-019-01230-z
  • Improvement of firocoxib dissolution performance through electrospun fibers obtained from different polymer/surfactant associations. Maggi L., Friuli V., Chiesa E., Pisani .S, Sakaj M., Celestini P., Bruni G. Int. J. Mol. Sci. (2019) 20 3084. https://doi.org/10.3390/ijms20123084
  • Probenecid and benzamide. I. Cocrystal prepared by a green method and its physico-chemical and pharmaceutical characterization. G. Bruni, F. Monteforte, V. Berbenni, L. Maggi, V. Friuli, C. Ferrara, P. Mustarelli, A. Girella, C. Milanese, A. Marini. J Thermal Analysis and Calorimetry (2020) 140:1859-1869. https://doi.org/10.1007/s10973-019-09197-2
  • Libri: Geomatrix Technology Delivery Systems for the Controlled Release of Drugs. L. Maggi, U. Conte. SEGNO&Forma Eds, Milano, I. (2003).
  • Pharmaceutical controlled-release tablet containing alfuzosin hydrochloride. PCT Int. Appl. WO 9808515, 5 marzo 1998. L. Maggi, U. Conte, P. Grenier, G. Vergnault, A. Dofour, F.X. Jarreau, C. Rauch-Desanti. (N° FR 9610551 USP6149940A1 ed Europeo: EP938318A1).
  • Gastroretentive gel formulations. G. Vergnault, U. Conte, L. Maggi. WO 2016/066256A1 May 6 2016
Collaborations

 

National collaborations

  • Prof. Giovanna Bruni
  • Prof. Doretta Capsoni
  • Prof. Marcella Bini Dip. di Chimica Università di Pavia
  • Prof. Dario Voinovich Università di Trieste
  • Prof. Francesco Castelli Università di Catania
  • Prof. Valter Travagli Università di Siena
  • Prof. Franco Pattarino e Lorena Segale Università del Piemonte Orientale
  • Dr. A. Canobbio SIGMAR italia Almè, BG.
  • Dr. R Novellini Giuliani, Milano.
  • Dr. F. Roversi Rofarma, Milano.

 

International collaborations

  • Dr. Stefano Salini, Dr. Alex Bolognini, Flarer Lugano, Skye Pharma Plc, Londra.
  • Prof. Nicolas Peppas, University of Texas at Austin.
  • Dr S. Palea, Palea Pharma & biutec consulting Toulose, FR.
Funded active projects

  • Study and evaluation of hybrid compounds to enhance the solubility of insoluble drugs.

Expertise

Tablet press equipped with thirty different types of punches, tablet press equipped for compression force measurements, mixers, granulators, fluid bed, twin impinger, dissolution and disintegration tests, equipment for the intrinsic dissolution rate measurement, friabilometer, precision electronic test for the crushing strength. Texture analyzer. Climatic chamber

Contacts

LAURETTA MAGGI - lauretta.maggi@unipv.it